07/10/2026
How much is SDMA really changing what we do in practice?
One of our members, Raquel, highlighted this really interesting systematic review looking at the diagnostic accuracy of SDMA for CKD in dogs and cats.
It is a really useful paper because, although SDMA is now widely used and included in IRIS guidance, the review suggests the evidence base is still far less certain than many of us might assume.
The authors identified 11 studies (5 feline, 6 canine) including just under 1000 animals, but found:
• major heterogeneity in study design and populations
• high risk of bias in most studies
• wide variation in sensitivity and specificity
• concern that SDMA may increase the risk of misdiagnosis and overdiagnosis
One particularly interesting point was the concern around specificity, especially in dogs. In one study, 54% of dogs with an elevated SDMA had a GFR that was not consistent with renal disease, suggesting a real risk of false positives if SDMA is overinterpreted, particularly in screening situations.
From my own perspective, I have to admit that SDMA has not dramatically changed my day-to-day clinical practice as much as I might have expected. I still find that creatinine, urine specific gravity, clinical context and trends over time tend to drive decision-making more than a single SDMA result.
Really interesting paper, and I would love to hear how others are using SDMA in practice.
If you enjoy discussions like this, we go into these kinds of diagnostic challenges in much more detail in our urinary CPD course:
🔗 https://vtx-cpd.com/courses/urinary-tract-disease-in-dogs-and-cats-from-a-to-pee-2/
The course explores the investigation and management of urinary tract disease in dogs and cats, including how to approach common presentations such as PUPD, urinalysis interpretation, UTIs, urolithiasis, and CKD staging and diagnosis.
📄 Scobie C, Dean R, Stavisky J, Pl?ddemann A.
Diagnostic accuracy of symmetric dimethylarginine for chronic kidney disease in cats and dogs: A systematic review.
Veterinary Record, 2026.