SirDan's Kennels

SirDan's Kennels Breeders of fine German Shorthaired Pointers.

Female Cavapoo - Update: Offering free delivery Christmas Day within a reasonable distance!Just in time for Christmas, w...
12/18/2025

Female Cavapoo - Update: Offering free delivery Christmas Day within a reasonable distance!

Just in time for Christmas, we have this lovely Cavapoo puppy, born August 3. "Pixie" was the runt in a litter of 6, and is doing well with her crate and house training. She is energetic, loving, and a good listener. Cavapoos are very intelligent and loyal. Email [email protected] for more.

Just in time for Christmas, we have this lovely Cavapoo puppy, born August 3. “Pixie” was the runt in a litter of 6, and is doing well with her crate and house training. She is energeti…

Born August 3rd. Vet checked with first shots and ready to go! These girls are so sweet, energetic, playful, and oh so l...
11/02/2025

Born August 3rd. Vet checked with first shots and ready to go! These girls are so sweet, energetic, playful, and oh so loving. Both parents on premises. Email [email protected] for more info.

Born August 3rd. Vet checked with first shots and ready to go!  These girls are so sweet, energetic, playful, and oh so loving. Both parents on premises. Email [email protected] for more …

10/31/2025

Wow!

Interesting info. We usually recommend spay or neuter after adulthood is reached, which tracks worth this information.
10/29/2025

Interesting info. We usually recommend spay or neuter after adulthood is reached, which tracks worth this information.

*Preventing unwanted litters is a goal we all share—but it's time to rethink the surgical approach. Hysterectomies and vasectomies, which preserve hormonal balance, can safely be performed as early as 8 weeks of age, making dogs sterile without disrupting their natural hormones.

New peer-reviewed study published in Nature:

How a dog’s lifetime exposure to his own hormones (before being neutered) affects how well he handles aging and frailty later in life.

Study Background

• Frailty = when older dogs (and people) become weaker, less resilient, and more prone to illness and death.
• Most research looks at how to prevent frailty — this study looked at what makes some dogs bounce back better after frailty sets in.
• The focus was on the HPG axis — the hormonal system that produces testosterone and controls reproduction.

Key Findings

• Dogs neutered very young (before 2 years old) had:

o A much higher risk of death once they became frail.
o About 16% higher mortality for every small increase in frailty.

• Dogs kept intact longer (more than ~10 years) showed:
o No increase in mortality linked to frailty.
o Their hormones seemed to “buffer” the negative effects of aging.

• Each extra year of natural hormone exposure reduced frailty-related death risk by ~1%.

What It Means

• Hormones from the te**es may protect against the worst effects of aging later in life.
• Removing them too early could make dogs less resilient to age-related decline.
• Frailty isn’t just about getting old — it’s also shaped by early-life events like the timing of neutering.
• This supports a “life course” view: what happens early in life affects health decades later.

Why It Matters

• The study suggests timing of neutering might influence how well dogs age.

Please email sirdanskennels@aol.com for details. All pups have been vet checked with first shots, have tails docked and ...
09/21/2025

Please email [email protected] for details. All pups have been vet checked with first shots, have tails docked and dew claws removed, and have been wormed.

Please email [email protected] for details. All pups have been vet checked with first shots, have tails docked and dew claws removed, and have been wormed. Males Male Male Female

Email sirdanskennels@aol.com for details. Champion bloodlines, beautiful dispositions. Tails docked to breed standard, d...
09/07/2025

Email [email protected] for details. Champion bloodlines, beautiful dispositions. Tails docked to breed standard, dew claws removed, vet checked with first shots, and wormed.

Email [email protected] for details. Champion bloodlines, beautiful dispositions. Tails docked to breed standard, dew claws removed, vet checked with first shots, and wormed. Female

08/30/2025

True! BTW, We have two liver white male puppies available, ready September 6.

One roan and 3 white. Vet checked w/ first shots, tails docked, and dew claws removed. They will be ready to go Septembe...
08/16/2025

One roan and 3 white. Vet checked w/ first shots, tails docked, and dew claws removed. They will be ready to go September 6. Email [email protected] for details.

One roan and 3 white. Vet checked w/ first shots, tails docked, and dew claws removed. They will be ready to go September 6. Email [email protected] for details.

Address

282 Hufnagel Road
Harmony, PA
16037

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