10/29/2026
Voice your support for the FDA’s recommended final rule change which will decrease dependency on animal testing requirements. It only takes a few minutes of your time. Comment by 12/7. Posting our comment below for reference 👇
“On behalf of 2nd Street Hooligans Animal Rescue, Inc., a non-profit animal rescue and sanctuary working with previous animal test subjects, we are writing in support of the Direct Final Rule for “Nonclinical Testing Terminology”(FDA-2026-N-5347). We strongly support the FDA updating its terminology from “animal” to “nonclinical” testing. This change is important because:
1. It aligns with the law: Congress already passed the Food and Drug Omnibus Reform Act (FDORA) to update this exact terminology. The FDA’s regulations should match the law.
2. It modernizes science: The new definition of “nonclinical” clearly includes modern, scientifically valid testing methods like cell-based assays, organ chips, and computer modeling. This gives drug developers more flexibility to use the best tools available.
3. It doesn’t add red tape: This rule does not impose new requirements on companies. It simply clarifies the language so that non-animal methods can be used to satisfy safety requirements where appropriate.
4. It helps prevent cruelty to animals.
As an organization that works with animals released from scientific testing facilities, we see firsthand the devastating effects of animal testing on innocent beings. Not only is testing on animals cruel and inhumane, it is largely wasteful. Animal-based results have a significant “fail” rate when they are carried out in later phases of testing, leading to unnecessary costs and suffering. This rule change, along with improved technology, will enable us to effectively move away from wasteful spending on animal-based testing while alleviating unnecessary suffering and improving and expediting scientific advancements.
Because these changes are noncontroversial and align with existing law,
We urge the FDA to finalize this rule as written without delay.
Thank you for the opportunity to comment.”
Credit to Amanda Olejarz for final slide language and public comment text inspiration.
