10/24/2025
Equine Protozoal Myeloencephalitis (EPM) is a serious neurologic disease in horses caused by protozoal infection of the central nervous system. Most cases are due to Sarcocystis neurona, but Neospora hughesi can also be responsible.
EPM is tricky to diagnose because its signs can mimic other health problems and range from mild to severe. Some of the common signs include incoordination, muscle atrophy (especially along the topline or hindquarters), abnormal gait, and weakness. It can also cause cranial nerve damage (facial paralysis, difficulty swallowing), behavioral changes, and even seizures.
If you notice any of these signs, contact your veterinarian promptly. Early detection and treatment can improve the chances of recovery.
If you'd like addition information about EPM, visit the Equine Disease Communication Center's website here: https://www.equinediseasecc.org/EPM