05/16/2026
π Quick veterinary science question: Do dogs have cannabinoid receptors?
Yes β and a lot of them. In fact, dogs have a notably high concentration of CB1 receptors in the cerebellum and brainstem, which is exactly why they're so responsive to cannabinoids like CBD β and exactly why THC is toxic to them even at small doses.
This is the endocannabinoid system at work, and it's one of the most important biological systems most pet owners have never heard of.
In this week's Ask Dr. Gaynor article, I break down:
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What the ECS is and what it does
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Why CBD modulates receptors without intoxicating effects β and THC doesn't
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What the 2018 Cornell osteoarthritis trial actually found
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Why full-spectrum matters (the entourage effect)
Read the full breakdown π https://peaktherapeutics.net/endocannabinoid-system-in-dogs/
β Dr. James Gaynor, DACVAA
Board-certified veterinarian explains the endocannabinoid system in dogs, how CBD interacts with it, and what peer-reviewed research shows.