18/04/2020
AHS VACCINATION NOTES APRIL 2020
Our visiting vet and good friend Dr Karl van Laeren BVSc MRCVS of Borrowdale Park Veterinary Hospital, Harare attended an AHS vaccination seminar in Kruger National Park in February 2020 and shared key info from that talk with us in early March. Following a Zoom chat on the outcomes with Karl and other clients of his in Botswana and Zimbabwe, I’d like to expand upon it as below.
Please note that these notes refer to the use of AHS vaccine from Ondersterpoort, South Africa. They are for the information and interest of horse owners and do not replace your own veterinarian’s advice.
New thinking in AHS vaccination
• The meeting was to discuss the current theory that no less than six sets of vaccination per horse are necessary to provide immunity.
• Therefore the recommendation is to give two full sets per year for three years in a row in previously unvaccinated horses.
• One full set is both bottles AHS 1 and AHS 2.
• This schedule will greatly enhance a horse’s chances of survival.
In the 19th century, some 70,000 horses died of AHS in South Africa in one ten year period, so although the vaccine is expensive to buy and can be challenging to source in some African countries, it is a big life saver when correctly used. More recently, in 2019, 50 race horses were lost in Thailand following the import of some zebra from South Africa. Thailand’s epidemic continues. https://asiatimes.com/2020/04/the-other-viral-plague-stalking-thailand/
Vaccination notes
• AHS is an attenuated (modified) live vaccine.
• To remain viable, the cold chain of above 4oC to 8oC MUST be preserved.
It cannot be frozen as this will kill it.
• When you are preparing it for use, it must be used within 10 minutes of
mixing, so when vaccinating big yards, do not mix too many doses at once.
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• Ideally, vaccination of the pregnant mare will start 3 months before the foal is born to provide it with passive immunity. This may last from 3 to 6 months, depending on the strains being examined.
• Knowing due date is therefore of key importance.
• Vaccination of any horse should take place outside the midge season i.e.
before the rains, as it is possible for the vaccine to cause a mild case of AHS which is transmissible by midges to other horses - because it is a live vaccine. This is known as viral recrudescence. It is more likely to occur in horses being vaccinated for the first time than in older horses being revaccinated.
• Vaccinate foals at age 6 months.
• Always use Bottle 2 before Bottle 1 to avoid reactions in sensitive
animals. Mild AHS symptoms are sometimes observed the very first time a youngster or mature horse receives AHS vaccine and these are usually less with Bottle 2 than Bottle 1.
Viral recrudescence was the cause of no less than 3 outbreaks of AHS in the Cape. Vaccine virus entered the midge population and rearranged itself into a more virulent strain which was then transmitted to adjacent unvaccinated horses with dire consequences. So – vaccinating in the non-midge season is very desirable in Southern Africa (June to end of October).
In East Africa where there are two rainy seasons, it may be necessary to use Bottle 2 in one dry season and Bottle 1 in the other, but local knowledge is required here to determine best practice.
Do not think that vaccinating your horses during an outbreak is going to save
them. It will not as they won’t have developed sufficient antibodies. Vaccine response is quite slow and one does not know which strain is at work. One may have been unlucky and started vaccinating with the wrong bottle.
For example, in 2020, strains 1, 4, 7 and 8 were all incriminated in the northern Transvaal and Gauteng (Limpopo province) outbreak. There are 9 serotypes in nature. Strains 1, 3 and 4 are in Bottle 1. Strains 2, 6, 7 and 8 are in Bottle 2. Strains 5 and 9 are not in but there is some cross protection from the strains that are present in the vaccine, between 8>5 and 6>9.
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A 2012 weanling study by Guthrie et all showed:
• 50% response to Serotype 1 within 3 weeks
• Serotype 3 response detected at 4 weeks
• Serotype 4 response detected at 7 weeks
• If Bottle 2 first only 27% response to Serotype 8!
• Foals born within 6 weeks of their dam’s vaccination had no response to
the vaccine
Research continues at Ondersterpoort (University of Pretoria, South Africa) and in Dubai at the Central Veterinary Research Laboratory.
SHN 16.4.2020
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BANGKOK – For the first time in Thailand, another rapidly spreading “cruel” and “devastating” virus has killed at least 186 horses by attacking the animals’ lung…