13/02/2025
Answer Case 6
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Persistent Hyperplastic Tunica Vasculosa Lentis/Persistent Hyperplastic Primary Vitreous (PHTVL/PHPV) is characterized by fetal and postnatal hyperplasia of the hyaloid system, tunica vasculosa lentis, and primary vitreous, resulting in a variable but often significant opacity. This disorder has been observed in cats and numerous dog breeds, with hereditary transmission documented in Bouvier des Flandres, Staffordshire Bull Terriers, and Doberman Pinschers. Research on Doberman Pinschers in the Netherlands suggests an autosomal incompletely dominant mode of inheritance with variable expressivity. Clinically, PHTVL/PHPV manifests as a white or fibrovascular plaque on the posterior lens capsule and anterior vitreous. Additional potential findings include vascular ingrowth and hemorrhage within the vitreous and lens cortex, calcium deposits, posterior lenticonus, microphakia, lens coloboma, intralenticular melanosis or hemorrhage, progressive cataracts, and elongated ciliary processes.