The Perseus Foundation

The Perseus Foundation Research.Discovery.Saving Lives.Finding Cures. The final phase of the study is currently in process.

Animal welfare organization with a focus on cancer research to benefit both pet companions and pediatric oncology patients. The Perseus Foundation provides financial assistance to pet owners who would otherwise not be able to treat, In Summer 2015 we formed a partnership with Aurelius Biotherapeutics to bring T Cell Therapy Infusion to dogs with B Cell Lymphoma.

🐾Types of Chemotherapy Drugs🐾Chemotherapy drugs are categorized into different groups based on how they work: Alkylating...
09/26/2025

🐾Types of Chemotherapy Drugs🐾

Chemotherapy drugs are categorized into different groups based on how they work:

Alkylating Agents: and Platinum Drugs: (Such as Cyclophosphamide). These are common types that work by preventing cells from replicating.

Antimetabolites: ( Such as Fluorouracil)These drugs interfere with the production of DNA and RNA.

Anti-tumor Antibiotics: ( Such as Mitoxantrone)These prevent cancer cells from dividing by damaging their DNA.

Topoisomerase Inhibitors: (Such as Doxorubicin)and Mitotic Inhibitors: (vincristine, vinblastine) These plant-derived compounds work by interfering with the normal process of cell division.

Corticosteroids: ( Such as prednisone) These are often used to reduce swelling and other side effects.

Chemotherapy Cycles.

What is a Cycle? A chemotherapy cycle consists of a period of treatment and a subsequent rest period.

Purpose of the Rest Period: The rest allows your body time to recover from side effects and build new, healthy cells, preparing it for the next round of treatment.

Cycle Length: Cycle lengths are not fixed and can vary from a few days to several weeks (e.g., 4, 7, 14, or 28 days).

Course of Treatment: A "course" of chemotherapy consists of a series of these cycles.

Factors in Planning: The specific drugs, the stage of the cancer, your overall health, and how your body responds to treatment all influence the frequency and length of cycles.

How Chemotherapy is Given
Intravenous (IV): Delivered through a vein in the arm or hand.
Oral: As pills or capsules taken by mouth.
Injections: Given as a shot into a muscle or under the skin.
Targeted Administration: In some cases, chemotherapy may be given directly into a body cavity or the spinal fluid.

Chemotherapy.  🐾Many dogs experience minimal or no side effects.  Dogs receive lower doses of chemotherapy drugs, which ...
09/26/2025

Chemotherapy.

🐾Many dogs experience minimal or no side effects. Dogs receive lower doses of chemotherapy drugs, which minimizes the risk of major side effects compared to human treatments. 🐾

Common chemotherapy side effects in dogs include gastrointestinal issues like nausea, vomiting, and diarrhea, and bone marrow suppression, which leads to a low white blood cell count, increasing infection risk. Some drugs can also cause hair loss, particularly in breeds with continuously growing hair, though this is less common. Other potential side effects include kidney, liver, and heart issues, along with bladder irritation.

Gastrointestinal (GI) Side Effects

Nausea, Vomiting, Diarrhea, and Constipation: These are the most common side effects and typically occur a few days after treatment.

Management: Often controlled with anti-vomiting medications, diet changes, and small, frequent meals

Bone Marrow Suppression

Neutropenia: A decrease in neutrophils (a type of white blood cell) that occurs 7-10 days after chemotherapy

Increased Infection Risk: A low white blood cell count weakens the immune system, making the dog more susceptible to infections.

Monitoring: Regular blood tests (Complete Blood Counts or CBCs) are used to monitor white blood cell counts.

Hair Loss
Affected Breeds: Dogs with hair that grows continuously, such as Poodles, Shih Tzus, and Bichon Frises, are more prone to significant hair loss.

Temporary: The hair usually grows back after chemotherapy is completed.

Changes: The new hair may be different in color or texture.

Other Potential Side Effects
Organ Damage: Some chemotherapy drugs can cause side effects affecting the kidneys, liver, or heart.

Bladder Irritation (Cystitis): Certain anticancer drugs can lead to bladder irritation.

Lethargy: A low white blood cell count can make dogs feel tired or lethargic.

Fever: A fever (temperature > 103°F) can be a sign of infection due to a low white blood cell count and requires immediate veterinary evaluation.

When to Contact Your Veterinarian
Contact your veterinarian immediately if your dog shows signs of sickness, such as:

When to Contact Your Veterinarian :

Contact your veterinarian immediately if your dog shows signs of sickness, such as:
Fever (temperature > 103°F)
Lethargy (tiredness)
Vomiting or diarrhea
Poor appetite
Signs of dehydration, such as dry or sticky gums

Cancerous cells, also known as malignant cells, are abnormal cells that have undergone uncontrolled growth and division....
09/26/2025

Cancerous cells, also known as malignant cells, are abnormal cells that have undergone uncontrolled growth and division. They differ from normal cells in several ways:

1. Proliferation: Cancer cells divide rapidly and continuously, ignoring the body's signals to stop dividing.
2. Invasion and Metastasis: They can invade and destroy surrounding tissues and spread to other parts of the body through the bloodstream or lymphatic system.
3. Immortality: Normal cells have a limited lifespan, but cancerous cells can evade cell death and become immortal.
4. Altered Appearance: Cancer cells may have an altered shape, size, and internal structure compared to normal cells.
5. Gene Mutations: Cancer cells often have genetic mutations that disrupt their normal function and lead to uncontrolled growth.
6. Immune Evasion: Cancer cells can evade the immune system by expressing proteins that mask them from immune cells.

Types of Cancerous Cells:
There are many different types of cancerous cells, depending on the tissue where they originate and their specific characteristics. Some common examples include:
Carcinoma: Cancer of epithelial cells (lining tissues)
Sarcoma: Cancer of connective tissues (bones, muscles, cartilage)
Leukemia: Cancer of blood cells
Lymphoma: Cancer of lymphatic cells

Conclusion:

Cancerous cells are abnormal cells that have acquired the ability to grow uncontrollably, invade tissues, and spread to other parts of the body. They are characterized by their altered proliferation, invasiveness, immortality, genetic mutations, and ability to evade the immune system.

Calvin’s look is priceless.  Party awaits and he is ready! Very ready. 🐾  Calvin is 12-years - young and a cocktail of c...
09/25/2025

Calvin’s look is priceless. Party awaits and he is ready! Very ready. 🐾 Calvin is 12-years - young and a cocktail of canine charisma. ⭐️He was treated for a fibrolipoma of the right maxilla with stereotactic radiation (SRS/SRT) by the PetCure Oncology team at SAGE Veterinary Centers.

Warmest Congratulations Sweet Calvin! We are rooting for you!

🐾It's understandable to find asking questions difficult during a pet cancer diagnosis due to emotion and information ove...
09/24/2025

🐾It's understandable to find asking questions difficult during a pet cancer diagnosis due to emotion and information overload; the best approach is to be prepared, write down questions, and take notes. Focus on your pet's specific diagnosis, the treatment options and their side effects, the prognosis, the costs, and your goals for your pet's quality of life. The oncologist can help guide the conversation, and don't hesitate to ask for clarification or information about supportive resources. 🐾

⏰ Before the Appointment

Talk to your primary veterinarian: to understand the diagnosis and any immediate concerns.

✅Make a list of questions: as they come to mind, even if they seem small or emotionally charged.

🤔Consider your goals: for your pet's treatment and quality of life.

📕Research: the type of cancer your pet has and treatment options, but don't feel you need to be an expert before the appointment.

During the Appointment

🙋‍♂️❓🙋‍♀️Inquire about the diagnosis: and what it means for your pet.

👨‍⚕️Inquire about all treatment options, their potential benefits, side effects, costs, and the time commitment involved.

🗣️Discuss prognosis and quality of life, including signs of pain and how to recognize when treatment may no longer be an option.

😬Don't be afraid to ask for clarification: if you don't understand something.

📝Take notes: to help remember information.
Ask for resources: on support groups, additional information, or potential clinical trials.
🐾🐾🐾🐾🐾🐾🐾🐾🐾🐾🐾🐾🐾🐾🐾

After the Appointment

🖊️Review your notes: and any information provided by the oncologist.

☎️Contact the clinic: if you think of new questions or have immediate concerns about side effects.

👩👨👩‍⚕️Consider joining: an online or in-person support group for pet owners facing cancer.

Consuder taking a perk st “ Talking To Your Vet” an excellent guide prepared by PetCure Oncology.

https://petcureoncology.com/wp-content/uploads/Talking-To-Your-Vet-About-Cancer-20240524.pdf

Our team is so happy to share some great news 🎉🐾🎉!Meet Vader, an adorable 9-year-old Border Collie Mix who was treated f...
09/23/2025

Our team is so happy to share some great news 🎉🐾🎉!

Meet Vader, an adorable 9-year-old Border Collie Mix who was treated for a mast cell tumor of the left carpus with stereotactic radiation (SRS/SRT) by the awesome PetCure Oncology Team at Thrive Pet Healthcare Specialists - Hoffman Estates in Antonio

Vader is the first graduate at the brand new San Antonio site. We think he is looking mighty handsome wearing his Pet Hero cape. 💛💙🧡

Warmest Congratulations Vader! 🎉❤️🎉

Precision Medicine: A New Era in Canine Cancer CarePrecision medicine for dogs is an advanced form of veterinary cancer ...
09/22/2025

Precision Medicine: A New Era in Canine Cancer Care

Precision medicine for dogs is an advanced form of veterinary cancer treatment that uses genomic testing to analyze the DNA of your dog’s tumor. By identifying specific genetic mutations driving the cancer, precision medicine allows veterinarians to recommend targeted therapies designed specifically for your dog’s unique cancer profile. This personalized approach moves beyond the traditional “one-size-fits-all” treatments like standard chemotherapy. Backed by compelling real‑world data and peer‑reviewed research, precision medicine gives pet parents hope by delivering more effective, compassionate care rooted in cutting-edge science

For years, canine cancer has been treated with standard chemotherapy and radiation—regardless of tumor type. But now, the same precision medicine used in human oncology is available for dogs. FidoCure uses genomic testing to identify the specific mutations driving your dog’s cancer. Based on these insights, your veterinarian receives a personalized report recommending one or more targeted therapies tailored to your pet’s unique cancer profile. Many treatments can be prescribed by your vet and given at home—making care more effective, personalized, and less stressful for you and your dog. FidoCure brings modern, science-driven cancer care to the pets who mean the world to us.

For detailed information visit http://https://fidocure.com/

https://www.medvet.com/precision-medicine-could-this-transform-the-way-we-treat-dogs-with-cancer/

INNOVATIVE TREATMENT, LIFE-CHANGING CARE FOR OUR PETS.Heartfelt thanks to PetCure Oncology for their excellence in care....
09/21/2025

INNOVATIVE TREATMENT, LIFE-CHANGING CARE FOR OUR PETS.

Heartfelt thanks to PetCure Oncology for their excellence in care. 💙 🐾❤️

Stereotactic radiation (SRS/SRT) is an advanced form of radiation therapy that has already been proven effective in treating humans with cancer. What sets SRS/SRT apart is its powerful and unprecedented precision, which now enables the treatment of some tumors that were previously considered untreatable.

SRS/SRT is a non-surgical therapy that puts a premium on your pet’s quality of life, resulting in far fewer treatment sessions, anesthetic events and side effects. 🐾🦴🐾

Another outstanding narrative by PetCure Oncology 🐾🐕‍🦺🐾🦮🐾Challenging Tumors: Adrenal Gland TumorsAdrenal tumors in dogs ...
09/16/2025

Another outstanding narrative by PetCure Oncology 🐾🐕‍🦺🐾🦮🐾

Challenging Tumors: Adrenal Gland Tumors
Adrenal tumors in dogs present a unique clinical challenge. While surgery remains the gold standard, not every patient is a candidate. High rates of vascular invasion and the potential for serious perioperative complications can make an adrenalectomy too risky. In these cases, stereotactic radiation therapy (SRS/SRT) offers a safe, effective alternative to surgical removal while preserving the patient’s quality of life.

This month’s feature in our “Challenging Tumors” series highlights a classic adrenal case, paired with emerging scientific evidence supporting SRS/SRT as a viable treatment option for adrenal tumors.

Clinical Background

The two most common adrenal tumor types in dogs are:
Functional cortical tumors—these are typically associated with Cushing’s disease (PU/PD, increase in appetite, panting, changes in body condition, and skin/hair coat).
Pheochromocytomas—these are catecholamine-secreting tumors that can cause changes in blood pressure, resulting in weakness, restlessness, and lethargy.
When a pheochromocytoma is suspected, pretreatment with phenoxybenzamine may be recommended to help reduce anesthetic complications. Confirming a diagnosis of a pheochromocytoma can be difficult, but suspicion can arise from clinical signs. A urine test is often necessary to help rule a pheochromocytoma in or out.

Adrenal cortical tumors, on the other hand, can be invasive and aggressive. About 20% invade nearby blood vessels, and roughly 50% will metastasize. A diagnosis of an adrenal cortical tumor may be confirmed if the patient is also confirmed to have Cushing’s disease.

The most effective treatment for adrenal gland tumors is surgical removal, which provides the best chance to alleviate symptoms and achieve a cure. The prognosis is generally favorable, with patients who survive the initial four-week perioperative period living an average of three years; however, the perioperative mortality rate is around 20%. When vascular invasion is present, the risk of surgical complications and mortality increases substantially.

When adrenal tumors extend into nearby structures or surgical removal carries a higher risk, stereotactic radiation therapy (SRS/SRT) may serve as a safe and effective alternative, including for families who are seeking less invasive options.

https://petcureoncology.com/wp-content/themes/petcure/images/logo.png

Powerful sentiments about working military dogs often highlight their unwavering loyalty, bravery, and the profound bond...
09/15/2025

Powerful sentiments about working military dogs often highlight their unwavering loyalty, bravery, and the profound bond they share with their human handlers. These heroes are consistently honored as selfless partners who save lives and provide immeasurable comfort under the most challenging circumstances.

We will forever hold Retired Sergeant Hottie, Arras, Turbo and Retired Sargeant Snap in our hearts.

A very special thank you to Dr. Edmund Sullivan, Bellingham Veterinary, Bellingham, Washington for providing top notch care for our heroes regardless of whether or not they are able to cover their cancer care costs.

Address

Nationwide
Washington D.C., DC

Alerts

Be the first to know and let us send you an email when The Perseus Foundation posts news and promotions. Your email address will not be used for any other purpose, and you can unsubscribe at any time.

Contact The Business

Send a message to The Perseus Foundation:

Share

Our Story

Animal comparative non profit with a focus on cancer research to benefit both pet companions and pediatric oncology patients. The Perseus Foundation provides financial assistance to pet owners who would otherwise not be able to treat, In Summer 2015 we formed a partnership with Aurelius Biotherapeutics to bring T Cell Therapy Infusion to dogs with B Cell Lymphoma. The first phase of the study is currently in process. The Teddy Bear Fund helps defray the cost of cancer care in cats. Our newest fund, The MiliDog Fund provides financial assistance for cancer care to our RWDs and CWDs. The Perseus Magic Fund, provides financial support for canine cancer patients enrolled in clinical trials, T Cell Therapy for B Cell lymphoma and Bone Marrow Transplants in dogs and SRS.