11/09/2024
Please beware of the risks of adverse events associated with isoxazoline flea and tick products.
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"Isoxazoline products have been associated with neurologic adverse reactions, including muscle tremors, ataxia, and seizures in some dogs and cats."
The FDA-approved drugs in this class are:
⛔️Bravecto (fluralaner) tablets for dogs
⛔️Bravecto (fluralaner) topical solution for cats and dogs
⛔️Bravecto Plus (fluralaner and moxidectin) topical solution for cats
⛔️Bravecto 1-month (fluralaner) tablets for dogs
⛔️Credelio (lotilaner) tablets for dogs and cats
⛔️Nexgard (afoxolaner) tablets for dogs
⛔️Nexgard Plus (afoxolaner, moxidectin, and pyrantel) chewable tablets for dogs
⛔️Nexgard Combo (esafoxolaner, eprinomectin, and praziquantel) topical solution for cats
⛔️Simparica (sarolaner) tablets for dogs
⛔️Simparica Trio (sarolaner, moxidectin and pyrantel) tablets for dogs
⛔️Revolution Plus (selamectin and sarolaner) topical solution for cats
The above were excerpted from the attached FDA issued warning. There have also been instances of death from these products.
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There are safer options for flea and tick control. For example, the original Revolution that contains only the selamectin works just as well for flea treatment and prevention but does not protect from as many species of ticks. Advantage II for cats does not contain any drugs of the isoxazoline class. There are others as well.
Note that even if your pet tolerated a flea or tick product without side effects on one application, they still can become sensitized to it upon repeat applications.
I recommend avoiding any products that are meant to last for more than a single month. That drug will not be able to be removed from them for the duration. Always weigh risks and benefits.
* Extra / 🙋🏻♀️🙋🏼♂️❓
See the comments for a link to tips for safe use of flea and tick products. Also, feel free to ask me questions. I'll do my best to answer. I have learned a lot from the different consultations I've had on these products and I will answer honestly when I don't know an answer.
FDA fact sheet about potential neurologic adverse events in dogs and cats when treated with the flea and tick drugs Bravecto, Credelio, Nexgard, or Simparica.