08/18/2025
When it comes to killing ticks, faster is always better. One of our four active
ingredients found in Credelio Quattro, lotilaner, was found to kill ticks* twice as fast†
as sarolaner in Simparica Trio® and afoxolaner in NexGard®.1
Fast† protection for your dog, and peace of mind for you. Schedule your next vet visit with us to learn
more about this new parasite protection.
Credelio Quattro, Elanco and the diagonal bar logo are trademarks of Elanco or its
affiliates. All other company and product names are trademarks of their respective
owners. ©2024 Elanco or its affiliates. PM-US-24-2087
Indications: Credelio Quattro is indicated for the prevention of heartworm disease and the treatment and control of roundworm, hookworm** and tapeworm infections. Credelio Quattro kills adult fleas and is indicated for the treatment and prevention of flea infestations and the treatment and control of tick infestations for 1 month in dogs and puppies 8 weeks of age and older and weighing 3.3 pounds or
greater.
Important Safety Information: Lotilaner, an ingredient in Credelio Quattro, belongs
to the isoxazoline class and has been associated with neurologic adverse reactions
like tremors, ataxia, and seizures even in dogs without a history of seizures. Use with
caution in dogs with a history of seizures or neurologic disorders. Dogs should be
tested for existing heartworm infections before Credelio Quattro administration as it
is not effective against adult D. immitis. The safe use in breeding, pregnant, or
lactating dogs has not been evaluated. The most frequently reported adverse
reactions in clinical trials were vomiting and diarrhea. For complete safety
information, please see Credelio Quattro product label or ask your veterinarian.
*Amblyomma americanum (lone star tick)
†
Based on the time to statistical significance vs. control in a single study on Day 21
and Day 28 for reinfestations.
1
Reif KE. et al 2017. “Comparative speed of kill provided by lotilaner (Credelio™),
sarolaner (Simparica Trio®), and afoxolaner (NexGard®) to control Amblyomma
americanum infestations on dogs.” Parasite Vectors. 2024 Jul 20;17(1):313.
**Uncinaria stenocephala