10/29/2026
Yesterday we talked about what a CHIC number means. Today, the other half of health-testing literacy: what a DNA test result actually says, and what it doesn't.
DNA testing for Cavalier King Charles Spaniels usually focuses on a small set of inherited conditions. The American Kennel Club lists three DNA tests for our breed: degenerative myelopathy (SOD1 gene), curly coat dry eye syndrome (FAM83H gene), and episodic falling syndrome (BCAN gene). All three are inherited in an autosomal recessive pattern, which is why the wording of a result matters so much.
Here's the plain-language version:
CLEAR means the dog has no copies of the tested variant.
CARRIER means the dog has one copy. Carriers are generally not expected to show clinical signs themselves.
AT-RISK (sometimes reported as affected) means the dog has two copies of the variant and is at risk of developing the condition, though other factors influence whether clinical signs actually appear.
So why would a caring breeder ever keep a carrier in a breeding program? Because genetics is a numbers game played across a whole breed, not a single dog. Guidance from Embark and The Royal Kennel Club is consistent: carriers should never be paired with other carriers, but pairing a carrier with a clear partner can produce healthy puppies while preserving genetic diversity. Excluding every carrier from breeding would shrink the breed's gene pool, and that carries its own inherited-health risks. The responsible approach is to test breeding stock, disclose results openly, and plan pairings deliberately.
If you're talking with breeders anywhere in Boring, Gresham, Portland, or across the Pacific Northwest, three fair questions:
1. Which DNA tests were run, and on which dogs? "The parents are tested" is weaker than being able to see the actual results.
2. If any dog is a carrier, how did that shape the pairing? A thoughtful answer that mentions the clear partner is a good sign.
3. What about conditions DNA tests don't cover? Genetic results are one layer only. Cardiac, eye, and patellar screening still matter enormously for Cavaliers, because the breed's most significant heart condition isn't identified by these DNA tests.
Honest limitations: DNA results reduce risk for specific tested variants. They cannot guarantee any individual puppy's lifetime health, they don't cover conditions with no available test, and they say nothing about temperament. And a familiar clarification from this series: health documentation does not confer or predict therapy-animal, service-dog, or emotional-support status, which depend on program evaluation, training, and specific legal definitions separate from breeding records.
This post is educational only. It is not veterinary, genetic, medical, therapeutic, behavioral, or legal advice, and it doesn't replace consultation with a veterinarian or a genetics-savvy breeder. No health or behavioral outcomes are guaranteed. Registry and testing requirements can change, and organization mentions are informational, not endorsements.
Sources accessed October 29, 2026: American Kennel Club, "Breed-Specific DNA Testing Recommendations"; American Kennel Club, "Understanding Autosomal Recessive Conditions in Dogs" (2024); American Kennel Club, "Genetic Testing in Dogs - an Overview" (2022); Embark, "Genetic Health Testing for Cavalier King Charles Spaniels" and "How do I interpret my results and use them to make breeding decisions?"; Embark for Breeders, "Responsible Breeding Practices"; The Royal Kennel Club, "Breeding advice for DNA test results"; Laboklin/Labogen, Cavalier King Charles Spaniel combination DNA panel (FAM83H, BCAN); OFA, "Degenerative Myelopathy" and "All DNA Tests."