NovaVive Inc. - Equine

09/29/2025

Equimune® immunotherapy is a potent stimulator of mononuclear cells, inducing the release of IL-1. Clinical studies have shown that horses treated with Equimune recover from respiratory disease complex sooner than horses treated with antibiotics alone.

In the early stages of a viral infection, Equimune reduces the time available for viral replication, the number of tissue cells affected, the degree of cellular damage and the duration of clinical signs and physiological abnormalities.

Learn more at NovaVive.ca/products.

09/25/2025

Immunocidin® Equine is a regulator-approved immunotherapeutic treatment for equine sarcoids. It is administered by intratumoral injection and is available to veterinarians in the USA and Canada.

Global sarcoid expert Professor Derek Knottenbelt of Equine Medical Solutions in the UK recommends an orthogonal plane injection method for better outcomes with fewer side effects.

“Although our primary focus has been on periocular sarcoids of different types, we have also used Immunocidin® Equine in other locations such as the flank field and face/cheek regions where other more conventional treatments are highly problematic.” (Prof. Derek Knottenbelt)

Learn more about Immunocidin® Equine at NovaVive.ca/products

09/23/2025

Please enjoy reading the latest quarterly business update newsletter from NovaVive - Volume 11, Issue 3 - https://tinyurl.com/yjz257us

For more information about us, visit www.NovaVive.ca

09/23/2025

At NovaVive, we develop immunotherapy products that harness the power of a horse’s own immune system.

Our equine therapies, Equimune®, Immunocidin® Equine and Settle®, are manufactured using a naturally occurring organism found in soil, Mycobacterium phlei. Through a specialized process, the organism is broken down into fractions that are highly recognizable to the immune system.

When injected, this material (MCWF – mycobacterium cell wall fraction) activates macrophages and lymphocytes, helping to stimulate both cell-mediated and humoral immune responses. The result is a powerful tool to support equine health.

Discover more about our technology here: NovaVive.ca/technology-overview

09/19/2025

NovaVive manufactures its equine immunotherapy products (Equimune, Immunocidin Equine and Settle) using a mycobacterium (M. phlei) as the source material. This organism is naturally occurring in soil.

Manufacturing involves growing and harvesting the M. phlei in a USDA-approved facility in Athens, Georgia, USA. This material is then processed through multiple steps including fractionation to make it more recognizable to an animal’s immune system when injected. The resulting material is called MCWF (mycobacterium cell wall fraction); this is suspended in phosphate-buffered saline and filled in glass vials.

MCWF activates macrophages and lymphocytes, inducing and enhancing both cell mediated and humoral immune responses in various species including the horse.

Learn more about NovaVive’s technology at http://novavive.ca/technology-overview

09/15/2025

Immunocidin® Equine is a regulator-approved, non-toxic treatment option for equine sarcoids. This intratumoral immunotherapy has a high tumor-free outcome rate and an excellent safety profile.

UK-based Professor Derek Knottenbelt, an equine internal medicine specialist with more than 50 years of experience treating sarcoids, has treated more than 150,000 sarcoids throughout his career. He now regularly uses or recommends Immunocidin Equine as a treatment option.

Prof. Knottenbelt has provided a 5-minute step-by-step video demonstration of the administration method that works best.

Contact NovaVive – [email protected] – for more information about sarcoid treatment with Immunocidin Equine.

In this video, Equine Medical Solutions staff describe the preferred option for intratumoral injection of equine sarcoids. They demonstrate the orthogonal pl...

09/12/2025

Have you heard? Settle® immunotherapy has been proven effective in reducing the amount of the hormone eCG in mares following pregnancy loss. Endometrial cups are placental tissues that invade the uterine lining and secrete eCG which leads to false pregnancy in the mare and often the inability to breed mares back in a breeding season.

No other treatment has been found effective in the early reduction/elimination of endometrial cups following pregnancy loss.

Researchers at the Gluck Equine Research Center at the University of Kentucky in collaboration with Rood & Riddle Equine Hospital conducted research with Settle for this condition, and the results have been published in the Equine Veterinary Journal.

Read more at https://pubmed.ncbi.nlm.nih.gov/38472105/

09/09/2025

NovaVive’s Equimune® immunotherapy can be used alongside vaccines.

Equimune has been tested in conjunction with a commercial West Nile virus (WNV) vaccine in horses. WNV is a mosquito-borne virus that causes inflammation of the brain and spinal cord of horses, producing neurological symptoms.

In the 50-horse (unpublished) study, Equimune was administered alongside the vaccine. A full dose of Equimune triggered more animals to seroconvert (generate antibodies in the blood) and triggered earlier seroconversion among the horses in the study.

Learn more about Equimune at NovaVive.ca/products.

09/06/2025

Cooler weather brings new demands on your horse’s immune system. Rather than waiting for illness to strike, take steps to boost their natural defenses.

Backed by clinical research, Equimune® immunotherapy has been shown to:
✔️ Shorten the duration of respiratory illness
✔️ Reduce viral replication and tissue damage in early infection
✔️ Enhance vaccine response, including with West Nile virus vaccine

A strong immune system is the best preparation for the seasons ahead. Learn more at NovaVive.ca/products

08/29/2025

Sarcoids might seem minor at first, but they can grow, spread, and become more difficult to treat over time.

Early intervention is key. Immunocidin® Equine is a regulator-approved intratumoral immunotherapy that helps stimulate the horse’s own immune system to target sarcoid tumors, gently and effectively.

Talk to your veterinarian about starting treatment early or learn more at NovaVive.ca/products.

08/26/2025

NovaVive is proud to be a leader in equine immunotherapy, developing advanced, regulator-approved treatments that activate the horse’s immune system to fight respiratory illness and sarcoids.

Our science helps horses stay healthier, longer.

Learn more about our equine products at NovaVive.ca.

08/21/2025

Immunocidin® Equine is the only regulator-approved intratumoral therapy developed specifically for treating equine sarcoids. Its safety and efficacy have been vetted by regulatory authorities, giving veterinarians and horse owners confidence in what they’re using because not all sarcoid treatments are created equal.

When your horse’s health is on the line, trust a solution that’s been thoroughly reviewed, not just recommended.

Learn more at NovaVive.ca/products.