06/05/2026
🐴 Gastrogard vs. Compounded Omeprazole: What Horse Owners Should Know About Gastric Ulcer Treatment
We are often asked about the difference between Gastrogard and compounded omeprazole products for treating gastric ulcers in horses.
Both contain the same active ingredient — omeprazole — but they are NOT equivalent products.
✅ Gastrogard is an FDA-approved omeprazole product specifically designed and tested for horses. It has been proven to reliably survive the horse’s acidic stomach environment and raise gastric pH to levels needed for ulcer healing.
⚠️ Compounded omeprazole products, on the other hand, can vary significantly in quality and stability.
Multiple independent studies have shown that compounded omeprazole products are often highly unstable and may rapidly lose potency. One widely referenced study evaluating compounded omeprazole from several U.S. and Canadian pharmacies found that many samples contained far less active drug than labeled, with substantial degradation occurring within days to weeks — even when stored properly.
Because these products frequently fail to reach therapeutic levels, they may not adequately increase stomach pH, which can result in poor ulcer healing or treatment failure.
While compounded medications can play an important role in veterinary medicine in certain situations, ulcer treatment is one area where formulation and stability matter tremendously.
If your horse is showing signs of gastric ulcers — poor performance, girthiness, weight loss, attitude changes, colic symptoms, or reduced appetite — speak with your veterinarian about the most effective treatment options.
📞 Have questions about equine gastric ulcers or treatment plans? Contact our clinic anytime.
Want to learn more about gastric ulcers? Check out this article: https://www.larchvetservices.com/new-page-4