PathoSense

11/06/2025

🔬 Excited to share our latest research contribution on an emerging pathogen threat in exotic reptiles.

PathoSense co-authored a study investigating a severe disease outbreak in imported juvenile caiman lizards

Key findings:

- Ferlavirus was identified as primary cause of respiratory and systemic disease. Sequencing indicated close relatedness with ferlaviruses from anacondas.
- Novel barthadenovirus and Cryptosporidium avium co-infections detected
- International pet trade highlighted as pathway for pathogen spread

This case demonstrates how comprehensive diagnostic approaches can uncover complex co-infections affecting exotic species. The identification of ferlaviruses in lizards adds to growing evidence of their broader host range beyond snakes.

Great work by Rachel Marschang, Camille Francois and all co-authors!

The link to the journal website can be found in the comments ↓

03/06/2025

🚀 A new podcast episode of "Pathogens in the Spotlight," is LIVE!

We're honored to have An Vanderzeypen from Zoetis, respected swine veterinarian, as our first guest. As a frequent PathoSense user, An provides a deep dive into how this diagnostic tool supports her in tackling challenging cases and improving swine health.

Learn from a true expert!

🎧Tune in: https://hubs.la/Q03qlcMS0

27/05/2025

🧬 Why Yeast Genome Sequencing Matters for Your Biotechnology Projects 🧬

When working with engineered yeast strains even the smallest genetic variation can significantly impact the efficiency and success of your production process. Having a precise and thorough understanding of your yeast genome is essential.

By accurately mapping the genome of your engineered yeast strains, PathoSense can detect and verify critical details such as plasmid integration sites, and chromosome integrity. This not only ensures that your genetic modifications are stable and functioning as intended but also helps you identify potential structural variants that could affect yeast performance.

Investing in yeast whole-genome sequencing allows you to save valuable time and resources by catching inconsistencies early, reducing trial-and-error, and optimizing strain performance for maximum yield and consistency.

Don’t leave your research and production outcomes to chance—gain clarity with PathoSense’s Yeast Whole-Genome Sequencing service: https://hubs.la/Q03g5JYc0

21/05/2025

Excited to announce a new partnership between PathoSense and FarmFaes, in collaboration with the University of Murcia! 🤝 🇪🇸
¡Encantados de anunciar una nueva colaboración entre PathoSense y FarmFaes, junto con la Universidad de Murcia! 🤝 🇪🇸

We've teamed up with FarmFaes to bring PathoSense diagnostic technology to Spanish farmers and producers. The University of Murcia will be processing all samples, ensuring high-quality and reliable diagnostics for livestock producers across Spain.

This makes Spain our 7th partner country in Europe - another step forward in our growing network across the continent.

The team caught in action at the FarmFaes booth (pictured) is ready to get to work combining their expertise in animal nutrition and health with our diagnostic solutions.

Good news for Spanish producers looking for better animal health management!

08/05/2025

🧬 Whole genome sequencing for biopharma applications

When developing vaccines or biological products, a lot of challenges are ahead but two critical questions constantly arise:
- Am I working with the right viral, bacterial or yeast strain?
- Are there unwanted adventitious agents in my early R&D samples or seed products?

Traditional testing methods require multiple PCRs - expensive, time-consuming, and limited in scope.
The good news? Regulatory landscapes are shifting toward Next-Generation Sequencing (NGS) as a comprehensive alternative.

Join our free webinar to discover how NGS and Whole Genome Sequencing can revolutionize your biopharma applications for:
- Viral (autogenous) vaccines: From early strain characterization to adventitious agent testing and with a particular focus on animal health industry
- Bacterial contamination QC: How 16S rRNA sequencing enables rapid decision-making when doing fermentation
- Yeast strain analysis: Identifying plasmid integration sites and structural variants
As scientists ourselves, we're excited to share practical applications that strengthen your quality control and accelerate development timelines.

What's your biggest challenge in ensuring biological product integrity? Do you want to share it below?
Free registration link in comments (recording available afterwards).

29/04/2025

What started as a passionate vision for revolutionizing infectious diagnostics in the animal health industry has now materialized into a state-of-the-art sequencing facility.

At PathoSense, our team of 9 dedicated scientists and professionals is driven by a simple yet powerful mission: to transform how we detect and manage infectious diseases and the microbiome in animals through cutting-edge sequencing-based innovation.

The journey hasn't always been easy. From late nights analysing data and cash flow planning to countless iterations of our sequencing platform, we've faced the challenges that all science-driven startups encounter. But today marks a significant milestone in our growth story.

Our new laboratory space represents more than just expanded capacity. It embodies our commitment to:
* Creating science-based solutions that veterinarians and the animal health industry can trust
* Building a company culture where innovation thrives

As we grow, we remain focused on durable development, scaling thoughtfully rather than rapidly. This ensures our foundation remains strong while we expand our horizons in animal health innovation. We keep our focus on our core strengths: animal health, infectious diseases & microbiome.

I'm incredibly proud of our small but mighty team, who made this possible. This laboratory isn't just a workspace; it's where breakthrough discoveries will happen. 🧪

So next time, when you are in Ghent, drop us a message and you can see our lab in real life.

24/04/2025

Join us on May 15th for an exclusive free webinar exploring how whole genome sequencing can revolutionize your research in yeast engineering, fermentation optimization, viral strain characterization, and autovaccine development.

Our expert panel will share cutting-edge insights on:
🦠 Accelerating strain development
🧬 Enhancing production through genomic analysis
🔬 Improving quality control with advanced sequencing techniques
🧪 Real-world applications across biopharma R&D

Whether you're optimizing fermentation processes or characterizing viral strains, this session will provide valuable strategies to advance your research.

Register now: https://hubs.la/Q03jGc270

15/04/2025

🧠💥 Did we get carried away with the latest AI trend?
Maybe…

🎨 Did we experiment a little too much with image generation?
Also maybe…

But hey — the PathoSense Action Sampling Kit is very real and ready for action!

Designed for all species and all sample types, it's your go-to kit for fast, reliable diagnostics.
📦 Available now at our amazing network of partner labs across Europe.
Find them all here 👉 https://hubs.la/Q03hrGkn0

🔍 How to collect high quality samples?
Read all about it here 👉 https://hubs.la/Q03hrGLq0

08/04/2025

When working with engineered yeast strains even the smallest genetic variation can significantly impact the efficiency and success of your production process. Having a precise and thorough understanding of your yeast genome is essential 🦠 🧬

In our upcoming webinar, we will explore why yeast whole-genome sequencing matters for your biotech and biopharma projects 🔬 From genome assembly to verifying critical genetic modifications, WGS helps to ensure that your yeast strains are perfectly optimized for your research and production needs.

Subscribe to our webinar and learn more about this topic! 👇
https://hubs.la/Q03g5QrY0

03/04/2025

Short-chain fatty acids (SCFAs) are initially produced as byproducts by the intestinal microbiota 🦠, but play a significant role in maintaining gut health and metabolic homeostasis in animals 🐖🐔🐄
Discover how these important metabolites are produced and absorbed in our latest blog post 👇
Did you know you can measure the SCFA profiles of your animal trial samples via PathoSense? Reach out to learn more: [email protected]

Explore the crucial role of short-chain fatty acids (SCFAs) in promoting and maintaining the gut ecosystem stability.

26/03/2025

PathoSense DeepDive: an new additional report for Viral Strain Characterization 🧬

PathoSense DeepDive provides phylogenetic trees and full genome insights based on your PathoSense Dx sample sequencing data. 🤿

Check out our latest blog post to get all the details — plus some real-world use cases you won’t want to miss! 🔍

👉 https://hubs.la/Q03dv_GH0

Uncover the potential of PathoSense DeepDive in advancing veterinary diagnostics with a focus on its applications, limitations, and case studies.

14/03/2025

🐏 Have you ever heard of Ovine Respiratory Syncytial Virus or ORSV?

As lamb season is getting in full swing, it is good to be vigilant for respiratory diseases in lambs and sheep. We detected a quite novel virus: ORSV

This virus was detected both in the Netherlands and Belgium with the PathoSense diagnostics this week.
The virus is moderately related to bovine respiratory syncytial virus in cattle. There is NO complete genome available in NCBI, only fragments. We created an entire genome from one sample, directly from the PathoSense analysis. We know that in bovines RSV can cause bronchiolitis and severe airway problems. In both cases in these sheep, severe co-infections with bacteria were present as well, indicating an ORDC (ovine respiratory disease complex). Amongst these bacteria we found Mycoplasma ovipneumoniae, Mycoplasma arginini, Helcococcus ovis, Fusobacterium necrophorum...

Good diagnostics is thus crucial, if you suspect problems in sheep/goats I would definitely recommend to use PathoSense. I am biased, I know, but PCRs will never show this amount of highly relevant information for sheep...