26/10/2023
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The cardinal signs of inflammation are a set of five classic symptoms that characterize the body's response to injury or infection.
These signs were first described by the ancient Roman physician Celsus and later expanded upon by the 19th-century pathologist Rudolf Virchow.
1. ππͺππ€π§ (ππππ£ππ¨π¨):
Increased blood flow to the affected area causes redness. This occurs due to vasodilation, where blood vessels widen to allow more blood to reach the site of injury or infection.
The red appearance is a result of more oxygen and nutrients being delivered to the area.
2. πΎππ‘π€π§ (ππππ©):
The increased blood flow also brings warmth to the affected area.
This heat is a consequence of the metabolic activity and increased circulation of blood, which carries immune cells and nutrients to aid in the inflammatory response.
3. ππͺπ’π€π§ (ππ¬ππ‘π‘ππ£π):
Accumulation of fluid, proteins, and immune cells leads to swelling at the site of injury.
Swelling serves a protective role by isolating the affected area and preventing the spread of harmful agents. It can also be a result of increased permeability of blood vessels.
4. πΏπ€π‘π€π§ (ππππ£):
Inflammation activates pain receptors, contributing to the discomfort or pain experienced at the site of injury.
Chemical mediators, such as prostaglandins and bradykinin, play a role in sensitizing nerve endings and transmitting pain signals.
5. ππͺπ£ππ©ππ€ ππππ¨π (ππ€π¨π¨ π€π ππͺπ£ππ©ππ€π£):
While not always included in every list, functio laesa refers to the functional impairment or altered function of the affected tissue or organ.
It highlights the impact of inflammation on the normal functioning of the body part and is considered the fifth cardinal sign.
Pict credit
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