
08/19/2025
Here's some interesting information about Polysaccharide storage myopathy (PSSM) from our friends at Rhinebeck Equine. Have you heard about this condition before? Let us know in the comments below!
"💪🏼 Last week, we discussed Exertional Rhabdomyolysis (ER) aka tying-up. We mentioned that PSSM (Polysaccharide storage myopathy) is associated with genetic susceptibility of ER.
💪🏼 What is PSSM?
PSSM is a disorder that causes muscle soreness and tying up in horses from abnormal glycogen storage in the muscles. The two types of PSSM are Type 1 and Type 2.
♦️ PSSM Type 1 is caused by a mutation in the GYS1 gene (glycogen synthase 1). The mutation causes muscle cells to produce glycogen continually. PSSM Type 1 is more commonly observed in Quarter Horses, Paints, Appaloosas and draft breeds; however, it has been documented in 20 breeds.
♦️ PSSM Type 2 occurs without genetic mutation yet results in abnormal glycogen storage in the muscles. It is still unknown the exact cause of PSSM Type 2. PSSM Type 2 is more common in warmbloods, but it has been linked to other breeds.
🩺 What are the clinical signs?
Sweating, lameness, sore muscles, weakness, undiagnosed lameness, poor performance, and muscle tremors that may occur with or without exercise. Not all horses will exhibit severe clinical signs.
🥼 How do we test for PSSM Type 1 and 2?
Testing for PSSM Type 1 requires hair samples with the roots attached to test for the GYS1 variant. Testing for PSSM Type 2 requires a muscle biopsy.
🩸 Additional testing of insulin may be warranted due to PSSM Type 1 horses are commonly more sensitive to it. Insulin causes the GYS1 gene to produce more glycogen.
💪🏼 How do we treat PSSM once diagnosis is made?
Diet and regular exercise are crucial to managing these horses. Often these horses are on a low non-structural carbohydrate (NSC) grass hay and a ration balancer. However, each horse is an individual and may need more calories which can be achieved by adding a low-NSC or high fat feed. Additional supportive care may be necessary during an active episode of tying up.
🤔 What is the prognosis?
Sadly, there’s no cure, but with dietary and exercise management horses can do well and reduce the frequency of active tying-up episodes."
If you have any concerns about your horse exhibiting signs of PSSM Type 1 or 2, talk to your veterinarian.
📸: Dr. Laura Javsicas, ACVIM, performing a muscle biopsy.