
08/16/2025
🧬 Key Neurological Effects of Pain on Behavior:
1. Sensitization of the Nervous System
Peripheral Sensitization: Damaged tissues release chemicals (like prostaglandins and cytokines) that lower the pain threshold at the site of injury.
Central Sensitization: The spinal cord and brain become more reactive to pain signals over time, even to normally non-painful stimuli—this is why chronic pain often leads to exaggerated or inappropriate responses.
🧠 Result: Dogs become more irritable, hypervigilant, and more likely to react strongly or aggressively to minor triggers.
2. Increased Activity in the Amygdala
The amygdala, a part of the limbic system, processes fear and threat. Chronic pain can cause heightened amygdala activation, increasing fear, anxiety, and aggression.
🧠 Result: A normally tolerant dog may begin resource guarding, react fearfully to touch, or become more noise-sensitive.
3. Suppressed Prefrontal Cortex Function
Pain affects the prefrontal cortex, which governs decision-making and impulse control. In dogs, this can manifest as:
Decreased frustration tolerance
Reduced capacity for training
Increased impulsivity or "reactivity"
🧠 Result: The dog may seem like they're "forgetting their training" or overreacting unpredictably.
4. Neurochemical Changes
Chronic pain alters the balance of neurotransmitters like serotonin, dopamine, and norepinephrine—all of which affect mood, motivation, and social behavior.
🧠 Result: You might see lethargy, depression-like symptoms, or avoidance behaviors.
🐾 Behavioral Red Flags Suggesting Pain
From a trainer’s or caregiver’s perspective, behaviors that could be rooted in pain include:
Sudden onset of aggression or reactivity
Avoidance of handling or interaction
Restlessness or changes in sleep
Resistance to movement or apparent "stubbornness" (no, dogs aren't stubborn)
Changes in posture or gait
"Shutdown" or disengaged behavior during training
🔍 Bottom Line
Pain doesn’t just hurt—it rewires the brain. That’s why a behavior change should always prompt consideration of a vet check.