03/09/2026
🐾 Let’s Talk About Cushing’s Disease in Dogs
Cushing’s disease is one of those conditions we see fairly often in veterinary medicine, especially in middle-aged to older dogs. The tricky part? The signs can creep in slowly, so many pet owners assume their dog is just “getting older.”
But sometimes there’s more going on.
What is Cushing’s disease?
Cushing’s disease (hyperadrenocorticism) happens when the body produces too much cortisol, a hormone made by the adrenal glands. Cortisol helps regulate stress, metabolism, and immune response — but when there’s too much of it, it starts affecting multiple body systems.
Common signs we look for:
• Increased thirst and urination
• Increased appetite
• Pot-bellied appearance
• Hair thinning or hair loss
• Panting more than usual
• Muscle weakness
• Recurrent skin infections
Many owners first notice their dog drinking the entire water bowl or asking to go outside much more often.
How do we diagnose it?
Diagnosis usually takes a combination of tests, not just one.
Your vet may recommend:
• Bloodwork and urinalysis
• Screening tests like a Low-Dose Dexamethasone Suppression Test (LDDS)
• ACTH stimulation test
• Abdominal ultrasound to evaluate the adrenal glands
These tests help determine whether the disease is coming from the pituitary gland (most common) or the adrenal glands.
Treatment options
The good news is that many dogs do very well with treatment.
Common approaches include:
• Medication (most commonly trilostane or mitotane) to control cortisol production
• Regular bloodwork monitoring
• In rare cases, surgery if an adrenal tumor is present
While Cushing’s can’t always be “cured,” it can often be managed successfully, allowing dogs to live comfortable, happy lives.
🐶 The takeaway:
If your dog suddenly seems extra thirsty, constantly hungry, or develops a pot-bellied look, it’s worth mentioning to your veterinarian. Sometimes those subtle changes are the body trying to tell us something