
22/07/2025
đŸ From Ultrasound to Spay: A Closer Look at Cystic Endometrial Hyperplasia (CEH)
This uterus pictured shows a very focal, exaggerated lesion representing an extreme version of something we see more often than weâd like: Cystic Endometrial Hyperplasia (CEH). I did include a picture of a normal happy uterus courtesy but of reddit.
Cystic endometrial hyperplasia, or CEH, occurs when the glands in the uterus overreact and cause hyperplasia, or thickening of the uterus. While this disease process is generally thought of as a progesterone influenced disease after a heat cycle, estrogen plays a vital role in the disease.
But hereâs the twist: while progesterone gets the spotlight, estrogen sets the stage. Estrogen "primes" the uterus for pregnancy, making it ultra-sensitive to progesterone. Unlike in humans, a bitchâs uterus doesnât slough or reset â meaning cumulative trauma can build over each cycle.
Progesteroneâs Role:
After every heat cycle (whether bred or not), progesterone:
1. Suppresses the immune system â Less defense = higher risk of pyometra
2. Stimulates gland secretion â Ideal for embryos⊠or bacteria
3. Closes the cervix â Traps any harmful content inside
4. Reduces uterine contractility â No flushing, just⊠storage
So yes, progesterone is a big deal. But it's not working alone.
â Why does the uterus overreact in the first place?
We donât have a simple answer â research is ongoing, and has been for years, and while treatments are being explored, no standardized treatment exists yet.
What we can say is this:
If your bitch consistently misses or has small litters despite good breeding management (proper timing, insemination, etc.), there may be more going on.
And unfortunatelyâŠ
đ A traumatized uterus isnât one a placenta can easily attach to â even a mildly affected one.
In this case, ultrasound made diagnosis easy â but thatâs not always true. Sometimes, only biopsy shows the real story.
Even though this is a exaggerated version of this disease process can you imagine a fetus trying to attach to this uterus, or even a less affected version. That's not happening.
đ¶âš Moral of the story?
Sometimes itâs not about the breeding plan â it's about whatâs happening inside the uterus. And while we do our best, even great vets aren't miracle workers. Weâre human, too.