18/05/2026
Time for our final look into blood gases.
Common Acid-Base Disturbances
• Respiratory Acidosis: Elevated PaCO₂, decreased pH. Causes include hypoventilation (e.g., airway obstruction, anaesthesia).
• Respiratory Alkalosis: Decreased PaCO₂, increased pH. Often due to hyperventilation (e.g., pain, anxiety).
• Metabolic Acidosis: Decreased HCO₃⁻, decreased pH. Causes include diarrhea, renal failure, shock.
• Metabolic Alkalosis: Increased HCO₃⁻, increased pH. Causes include vomiting (loss of gastric acid), diuretic use.
Clinical Applications in Veterinary Medicine
Blood gas analysis is particularly useful in the following scenarios:
• Respiratory distress or failure: Evaluates if hypoxia is present and whether it is due to pulmonary or extrapulmonary causes.
• Trauma or shock: Assesses tissue perfusion and acid-base disturbances.
• Anaesthesia monitoring: Monitors ventilation and oxygenation during surgery.
• Critical care: Guides therapy in patients with sepsis, metabolic diseases, or multi-organ dysfunction.
Practical Tips for Veterinary Nurses
• Always use a heparinized syringe and avoid introducing air bubbles.
• Label the sample accurately (arterial vs. venous, patient details, time collected).
• Analyse samples promptly; if delay is unavoidable, keep the sample on ice and process within 30 minutes.
• Be familiar with the operation and maintenance of the blood gas analyzer in your clinic.
• Work closely with veterinarians to interpret results in the context of the patient’s clinical presentation.
Limitations and Potential Errors
Blood gas analysis, while invaluable, has limitations:
• Pre-analytical errors: Air contamination, delayed analysis, improper storage can all skew results.
• Species variation: Normal reference ranges vary among species; always use appropriate reference values.
• Sample type: Using venous blood for oxygenation assessment can lead to misinterpretation.