
08/08/2025
Did you make the correct diagnosis?
Image A is an anterior lens luxation, while image B is nuclear sclerosis.
In the labelled version of Image A, black arrows outline the lens equator while a white arrow points to the only visible pupillary margin. Note how the lens equator is visible 360 degrees, indicating the lens has completely luxated into the anterior chamber, and virtually none of the pupillary margin is visible. Additionally, there is moderate edema of the axial cornea because the lens is compressing the posterior cornea and causing endothelial dysfunction and endothelial cell loss. Note that the area of corneal edema is roughly the same size as the lens.
In the labelled version of Image B, the single black arrow points to the pupillary margin, while the single white arrow points to the lens nucleus. Nuclear sclerosis is a normal aging change that results in the center of the lens (the nucleus) becoming more dense than the periphery (the cortex). The features that distinguish nuclear sclerosis are: dog > 7 years old, bilaterally symmetric, and a pearlescent and perfectly circular appearance. You can see a normal tapetal reflection through nuclear sclerosis, and vision is not affected. By contrast, most dogs with acute anterior lens luxation do not have a normal menace response. Many older dogs have iris atrophy, which is age-related weakening of the iris muscles that leads to consistent and persistent mydriasis. The dog in image B has severe iris atrophy, which is why the pupil is so dilated and why the lens nucleus with nuclear sclerosis can be seen so clearly. One feature that helps distinguish this nuclear sclerosis from an anterior lens luxation is the pupillary margin is visible 360 degrees. There is no visible lens equator, which also distinguishes nuclear sclerosis from a posterior lens subluxation.