21/06/2025
DRONTAL
Is it the perfect poison for your pet?
Lets take a look see at the manufacturer and the ingredients for the wormer..
This company was bought by Boehringer Ingelheim who happen to have a partnership with the veterinary associationā¦.I can guarantee that these vets are not holistic, or even integrated. Conventional vets donāt do raw, in fact they are anti-raw. You may already have found this. This product Paragard.. Keeping in mind that these poisons never leave the dogs system..Over time, the body absorbs more.
When they look at toxicity level, they don't test for organ damage, only symptoms that we see happening:
First ingredient..
Praziquantel
Toxic SYMPTOMS are, Salivation (drooling), Depression, Vomiting and Ataxia (uncoordinated movements).
Remember this is symptoms, not damage to organs.
Reported adverse events include vomiting, depression/lethargy, diarrhea, anorexia and 13 instances of death.
Acute Toxicity and Tolerance of Praziquantel
LD50 acute, mice, p.o. 2000-3000 mg/kg
LD50 acute, mice, s.c. 7000 mg/kg
LD50 acute, mice, i.p. >2000 mg/kg
LD50 acute, mice, i.m. >2000 mg/kg
LD50 acute, rats, p.o. 2000-3000 mg/kg
LD50 acute, rats, s.c. 16000 mg/kg
LD50 acute, rats, i.p. 600-800 mg/kg
LD50 acute, rats, i.m. >1000 mg/kg
LD50 acute, dogs p.o. >200 mg/kg.
In dogs, daily administration of 60 to 180 mg/kg during 4 weeks cause no sings of toxicity. Parenteral doses of 200 mg/kg caused transient vomit, salivation (drooling) and/or depression...
So take the dose, compare it with the above and the amount of times you use it.... THERE you have toxicity levels in organs.
They measure toxicity by symptoms seen, not the damage it does to the dogs organs etc.
See comments for links
Second ingredient..
Pyrantel
This is the active ingredient in DrontalĀ® Plus, PRO-Wormer 2Ā®, NemexĀ®-2 etc. Side effects include vomiting, depression/lethargy, anorexia and 204 instances of death.
This is the active ingredient in DrontalĀ® Plus, PRO-Wormer 2Ā®, NemexĀ®-2. etc. Side effects include vomiting, depression/lethargy, anorexia and 204 instances of death.
Acute Toxicity and Tolerance of Pyrantel
Pyrantel tartrate is more soluble in water than pyrantel pamoate. Consequently absorption of the tartrate into blood is higher, which results in a higher toxicity.
LD50 acute, rats, p.o. tartrate ~170 mg/kg
LD50 acute, rats, p.o. pamoate=embonate >5000 mg/kg
LD50 acute, mice, p.o. tartrate ~170 mg/kg
LD50 acute, dog, p.o. pamoate=embonate >690 mg/kg
You do the math for this ripper..
In dog studies for sub-chronic toxicity, animals treated at 20 mg/kg/day during 3 months didn't show toxic symptoms, but at 50 mg/kg/day they showed symptoms of intoxication.
Remember these are SYMPTOMS ONLY.
Toxic Symptoms caused by Pyrantel Poisoning
Most frequent intoxication symptoms are cholinergic:
Tachycardia (accelerated heart rate)
Salivation (drooling)
Hyperhidrosis (excessive sweating)
Diarrhea
Vomit
Tremor (uncoordinated trembling or shaking movements)
Convulsions
Excitation
Ataxia (uncoordinated movements)
Third ingredient..
Oxantel
Acute Toxicity and Tolerance of Oxantel
LD50 acute, rats, p.o. 980 mg/kg
LD50 acute, mice, p.o. 300 mg/kg
LD50 acute, rabbit, p.o. 3200 mg/kg
Dogs tolerate oxantel very well, due to its low toxicity and its reduced absorption to blood after oral administration.
Safety margin of oxantel pamoate in dogs is ~15.
Toxic Symptoms caused by Oxantel Poisoning
Most frequent intoxication symptoms are nausea, vomit, diarrhea and loss of appetite.
Oxantel Side Effects, Adverse Drug Reactions (ADRs) and Warnings
Adverse drug reactions after therapeutic doses are similar to those after overdosing (mainly nausea, vomit, diarrhea and loss of appetite), but at a lesser degree.
NO antidote for poison.
SEE COMMENTS FOR LINKS
