07/05/2025
This is incredible news!!
This could be the beginning of a global antivenom, accessible to everyone. This has been the single biggest issue with venomous snake bites around the world.
Over two decades, Tim Friede, a Wisconsin man with no formal scientific training, subjected himself to over 200 snake bites and 650 venom injections in a quest to build immunity to some of the world’s deadliest snakes. His unconventional approach caught the attention of immunologist Jacob Glanville, who believed Friede’s blood might contain broadly neutralizing antibodies. Glanville and his team extracted two such antibodies from Friede’s blood and combined them with varespladib, a molecule that inhibits venom enzymes. This combination was tested on mice exposed to venom from various elapid snakes, including mambas, cobras, taipans, and coral snakes. The results were promising: thirteen mice were fully protected, and the remaining six showed partial immunity .  
Traditional antivenoms are species-specific and often derived from animal antibodies, which can cause severe allergic reactions and are expensive to produce. In contrast, the antibodies from Friede’s blood offer a potential pathway to a universal antivenom that is lab-produced, potentially reducing costs and allergic risks. While Friede’s methods are not recommended for others, his contributions have provided a unique opportunity for scientists to develop a more effective and broadly applicable antivenom. The research team plans to conduct further testing, including trials on dogs in Australia, before moving on to human trials .